Diurnal variation in airflow obstruction in chronic bronchitis.

Diurnal variation in airflow obstruction in chronic bronchitis.

Twelve patients fulfilling strict criteria for chronic obstructive bronchitis recorded serial peak expiratory flow rates (PEFR) five times daily for a two-week period. Despite a 9.2% improvement in forced expiratory volume in one second (FEV1) with ipratropium bromide, and an 11.3% improvement with ipratropium bromide plus salbutamol, the inherent diurnal variation in PEFR while on no medicatio...

Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness.

The response to inhaled methacholine is increased in patients with chronic airflow obstruction, but it is not known whether this is due to true hyperresponsiveness or is a result of the airflow obstruction. In asthmatics the response to methacholine correlates with the bronchoconstriction produced by hyperventilation of cold dry air. We studied 27 patients with a history of smoking and chronic ...

Reversibility of airways obstruction in chronic bronchitis.

1. Airways resistance and lung volume were measured in twenty-five patients with chronic bronchitis and fifteen patients without chest disease before and after the inhalation of isoprenaline. Similar measurements were made on fourteen of these patients with chronic bronchitis and twelve other patients without chest disease before and after the intravenous injection of atropine sulphate. 2. Ther...

Aspects of chronic airflow obstruction.

This report questions several commonly used definitions and commonly accepted concepts. It suggest that the term, "chronic airflow obstructions," should replace the terms, "chronic obstructive pulmonary disease," "chronic obstructive lung disease," or "chronic airway obstruction," because it is flow that is obstructed. It is suggested the term, "chronic mucous hypersecretion," be used, rather t...

Definitions of emphysema, chronic bronchitis, asthma, and airflow obstruction: 25 years on from the Ciba symposium.